Margaret Hepburn
- 1542(
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- 1 Margaret Hepburn [1] d. 11 Jun 1542
- 3rd Lord Sinclair Henry Sinclair
- 2 Agnes Sinclair [1.1] d. 22 Feb 1574
- 3rd Earl of Bothwell Patrick Hepburn b. 1512 d. Sep 1556
- 3 4th Earl of Bothwell James Hepburn [1.1.1] b. 1535 d. 19 Apr 1578
- + Jean Gordon
- + Queen of Scotland Mary Queen of Scots Stewart b. 7 Dec 1542 d. 8 Feb 1587
- + Jean Gordon
- 3 Jane Hepburn [1.1.2] b. 1540 d. 27 Jul 1599
- 1st Lord Darnley John Stewart b. 1531 d. 1563
- 4 Francis Stewart [1.1.2.1]
- 4 Francis Stewart [1.1.2.1]
- 5th of Whittingham Archibald Douglas b. Bef 1540 d. 1588
- 4 Elizabeth Douglas [1.1.2.2]
- 4 Elizabeth Douglas [1.1.2.2]
- 3 4th Earl of Bothwell James Hepburn [1.1.1]
- 2 Agnes Sinclair [1.1]