Family: 3rd Earl of Bothwell Patrick Hepburn / Agnes Sinclair (F3590)
m. 1533
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2nd Earl of Bothwell Adam Hepburn (1492-1513)
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Margaret Hepburn ( -1542)
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| 3rd Earl of Bothwell Patrick Hepburn (1512-1556)
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| Agnes Sinclair ( -1574)
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4th Earl of Bothwell James Hepburn (1535-1578)  |
| Jane Hepburn (1540-1599) |